Synbiotic preparation with Lactic acid bacteria and inulin as a functional food: In vivo evaluation of microbial activities, and preneoplastic aberrant crypt foci

Colorectal cancer (CC) is one of the major health problems with the vast incidence in developed countries. Currently, the incidence and mortality of CC increased rapidly in Asian countries (Pourhoseingholi, 2012). Diet, environment and lifestyle play a significant role in carcinogenesis. The increase in CC incidence is parallel with economic development and adoption of a western way of life (Center et al., 2009). Epidemiological studies suggested that consumption of high-fat diet, red meat, and processed meat, could be associated with the contribution of CC risk (Huxley et al., 2009; Chan et al., 2011). However, fiber-rich diet appeared to be protective against CC (Riboli & Norat, 2003). Scientific evidences revealed that colonic microflora have a significant role in the cause of CC by altering the metabolome and the transcriptome of the host (Louis et al., 2014; Dhtani, 2015).